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PRECAUTIONS General Interference with Cognitive and Motor Performance Studies indicate that BuSpar is less sedating than other anxiolytics and that it does not produce significant functional impairment. For example, buspirone may increase central noradrenergic alternatively, the effect may be attributable to dopaminergic effects ie, represent akathisia. Do not start, stop or buy mail order buspar change the dosage of any medicine before checking with them first. These pharmacokinetic interactions were accompanied by an increased incidence of side effects attributable to buspirone.